學研新創 - 智慧醫療與健康科技
以居家血壓預測心血管疾病風險的機器學習模型
2022-12-20
鄭浩民教授團隊/臺北榮民總醫院

鄭浩民、蕭邱漢、游博鈞、謝佳穎、鍾秉諮、蔡祐琳、洪群崴、張瑋倫、林永松、黃彥男

近年來許多研究指出,居家血壓有助於高血壓的診斷、治療及預後。台灣高血壓學會和中華民國心臟學會建議,居家血壓測量應遵循722原則,以利掌握病患更真實的血壓數值和變異狀況,有助於提升預測心血管疾病發生風險的準確性。本團隊基於這個趨勢,分析來自台灣多家醫學中心共同參與的台灣高血壓相關心臟疾病臨床試驗聯盟所招募之2820位高血壓病患之居家血壓等生理數據,與其健保就醫資料串連,並且使用來自跨洲多國的居家血壓資料庫International Database of Home blood pressure in relation to Cardiovascular Outcome (IDHOCO),以深度學習、機器學習或統計分析等方法建立風險預測模型,並制定預警機制。實驗結果顯示,精準度最高的三個模型為:Random Forest、Decision Tree bagging、XGBoost,最高準確率和AUC皆超過0.95。本計畫除了利用個人的居家血壓和生理數據之外,規劃加入中央氣象局所提供之氣溫資料及環境保護署所公布之空氣品質數據,以增強模型的疾病風險預測能力,進一步實現P4醫療(Predictive, Preventive, Personalized, Participatory)的目標。

評審推薦
1.本案以深度學習、機器學習及統計分析等方式建模,找出合適的血壓預測系統,提出以居家血壓作為心血管疾病預測模型,並考量氣溫或空汙等變因,有助於疾病預防推動。
2.整體模型加入氣溫參數後,短、中、長期的預測準確度達到0.9以上,最高之AUC為0.96;未來將加入空汙資料,增強模型穩定性和準確率。
團隊簡介

鄭浩民

學歷

Doctorate degree in Medicine

現職

臺北榮民總醫院教學部教師培育科主任/心臟內科主治醫師

陽明交通大學醫學院內科學系教授/公共衛生研究所教授/衛生福利研究所合聘教授

台灣實證醫學學會秘書長

台灣高血壓學會理事

台灣皮質醛酮症學會常務理事

經歷

1) Professor Cheng has been a cardiologist for more than 15 years with the sub-speciality of interventional cardiology and cardiovascular hemodynamics.

2) As a professor in National Yang Ming Chiao Tung University, He has been granted the awards of excellence in Clinical and Internship Teaching numerous times.

3) Professor Cheng is current the director of Division of Faculty Development, Taipei Veterans General Hospital and was the immediate past director of Centre for Evidence-based Medicine in Taipei Veterans General Hospital.

4) His research has been focusing on cardiovascular hemodynamics, hypertension management, and evidence-based health care with more than 250 articles published in peer-reviewed journals and several patents in US, Japan, and Taiwan.

5) Professor Cheng is an editor in Systematic Reviews, BMC Cardiovascular Disorders, JBI evidence synthesis, Frontiers in Cardiovascular Medicine and has been involved in editorial and peer-review work of many international SCI listed journals.

6) Professor Cheng has developed the innovative techniques relating to cardiovascular hemodynamics and endeavoured to facilitate the technology transfer from research to industrialisation.

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